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NEJM - Colección Diabetes

Weight and Metabolic Outcomes 12 Years after Gastric Bypass
21/9/2017
ver resumen
The first surgical procedure performed specifically for weight loss took place in 1954. Since then, bariatric procedures have become less invasive and safer, and insights regarding the beneficial metabolic effects of such procedures have led to additional indications for these procedures.…

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes
14/9/2017
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The risk of death from any cause among persons with type 2 diabetes is up to twice that of the general population, and the risk of death from cardiovascular causes is up to four times that of the general population. Improved glycemic control has been shown to improve microvascular outcomes, but a…

Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes
13/9/2017
ver resumen
The incidence of type 1 diabetes, which currently affects 29 million adults worldwide, is rising. In the United States, the number of patients with type 1 diabetes who are younger than 20 years of age may triple within 30 years. Less than one third of adults with type 1 diabetes achieve a glycated…

Adjunctive Treatments for Type 1 Diabetes
13/9/2017
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The proliferation of new drug treatments for type 2 diabetes in the United States in the past 15 years, with more than 17 drugs approved in six new classes of antidiabetic drugs, has been promoted by several factors. First, the recognition of the importance of intensive glycemic control to reduce…

Liraglutide and Renal Outcomes in Type 2 Diabetes
31/8/2017
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Persons with type 2 diabetes mellitus, particularly those with evidence of cardiovascular disease, are at high risk for chronic kidney disease. In most countries, diabetic kidney disease is reported to be the leading cause of dialysis-dependent chronic kidney disease. Efforts to blunt the global…

A New Chapter for Diabetic Kidney Disease
31/8/2017
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Many clinical outcomes have improved over the past two decades for people living with diabetes. However, relatively little progress has been made in the treatment of diabetic kidney disease. Among adults with diabetes in the United States, the prevalence of diabetic kidney disease has remained…

Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes
24/8/2017
ver resumen
Cardiovascular complications remain two to four times more common among patients with type 2 diabetes than among persons without diabetes. Observational studies have suggested that patients with type 2 diabetes who require insulin have increased rates of cardiovascular events. However, a large…

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
17/8/2017
ver resumen
Type 2 diabetes mellitus is associated with a substantial risk of cardiovascular and renal disease. The use of inhibitors of sodium–glucose cotransporter 2 (SGLT2) results in favorable effects on biomarkers, including glycemia, blood pressure, weight, intrarenal hemodynamics, and albuminuria, and…

Insulin-Mediated Lipohypertrophy
10/8/2017
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Figure 1.

Diabetic Foot Ulcers and Their Recurrence
15/6/2017
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Complications of diabetes that affect the lower extremities are common, complex, and costly. Foot ulceration is the most frequently recognized complication. In a community-based study in the northwestern United Kingdom, the prevalence of active foot ulcers identified at screening among persons with…

Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor
8/6/2017
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To the Editor: Inhibitors of sodium–glucose cotransporter 2 (SGLT2) decrease plasma glucose by blocking the reabsorption of glucose at the proximal tubule. Case reports have suggested that SGLT2 inhibitors may be associated with an increased risk of diabetic ketoacidosis, which led to a warning…

Bioengineering of an Intraabdominal Endocrine Pancreas
11/5/2017
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To the Editor: Islet transplantation can restore euglycemia and eliminate severe hypoglycemia in patients with type 1 diabetes. Limitations of intrahepatic islet transplantation include a restricted transplant-tissue volume, bleeding with placement of the transplant, exposure to high levels of…

Academic, Foundation, and Industry Collaboration in Finding New Therapies
4/5/2017
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Breakthroughs in the ability to probe and better understand biologic systems during the past 30 years have enabled the medical community to develop new therapeutic agents and change the course of many life-shortening diseases. Despite this success, bridging the gap between promising laboratory…

Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes
20/4/2017
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Diabetic retinopathy is the most common cause of blindness in adults in the United States. Fortunately, the risk of the development and progression of retinopathy can be reduced substantially by modern-day intensive glycemic management. Moreover, if clinically significant macular edema or…

Screening for Diabetic Retinopathy
20/4/2017
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Screening tests are performed in asymptomatic persons to assess for the presence of a particular disease or the risk of that disease. An effective screening test should reduce morbidity and mortality in a population by detecting disease at a stage at which treatment will make a difference. However,…

Diagnosis and Differential Diagnosis of Cushing’s Syndrome
13/4/2017
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More than a century ago, Harvey Cushing introduced the term "pluriglandular syndrome" to describe a disorder characterized by rapid development of central obesity, arterial hypertension, proximal muscle weakness, diabetes mellitus, oligomenorrhea, hirsutism, thin skin, and ecchymoses. Cushing knew…

Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes
13/4/2017
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Diabetes mellitus is a complex and heterogeneous group of chronic metabolic diseases that are characterized by hyperglycemia. Type 1 diabetes occurs predominantly in young people (diagnosis at 30 years of age or younger) and is generally thought to be precipitated by an immune-associated…

Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012
13/4/2017
ver resumen
Diagnoses of type 1 and type 2 diabetes in youths present a substantial clinical and public health burden owing to the challenges of disease management and the risks of acute and chronic complications. The SEARCH for Diabetes in Youth study (hereafter, the SEARCH study) previously showed increases…

Increase in the Incidence of Diabetes and Its Implications
13/4/2017
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Diabetes mellitus is among the most prevalent and morbid chronic diseases, affecting the health of millions of persons worldwide. According to the Global Burden of Disease (GBD) report for 2015, the prevalence of diabetes rose from approximately 333 million persons in 2005 to approximately 435…

Glucagonoma-Associated Rash
9/3/2017
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Figure 1.






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