JAMA más leídos

JAMA más leídos 2017-01-13T09:38:31+00:00

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JAMA - más leídos

The Mediterranean Diet’s Fight Against Frailty
15/5/2018
Voelker R.
ver resumen
This Medical News story describes mounting evidence that shows a Mediterranean diet rich in plant-based foods may reduce older adults’ risk of becoming frail.

USPSTF Recommendation: Screening for Prostate Cancer
8/5/2018
, Grossman DC, Curry SJ, et al.
ver resumen
This 2018 updated Recommendation Statement from the US Preventive Services Task Force concludes that clinicians should not screen for prostate cancer in men aged 55 to 69 years who do not express a preference for screening (C recommendation) and recommends against PSA-based screening in men 70 years and older (D recommendation).

Another Nail in the Coffin for Fish Oil Supplements
8/5/2018
Abbasi J.
ver resumen
This Medical News article discusses a recent analysis of 10 clinical trials of omega-3 fatty acid supplements for heart health.

Comparison of Intubation Techniques in Patients With Difficult Airways
16/5/2018
Driver BE, Prekker ME, Klein LR, et al.
ver resumen
This randomized clinical trial compares the effect on first-attempt success of intubation using a tracheal tube bougie introducer vs endotracheal tube with stylet in patients with difficult airway characteristics requiring emergency intubation.

Consensus Definitions for Sepsis and Septic Shock
23/2/2016
Singer M, Deutschman CS, Seymour C, et al.
ver resumen
This article presents updated definitions of and clinical criteria for diagnosing sepsis and septic shock based on recommendations from an expert task force.

In the Era of Precision Medicine and Big Data, Who Is Normal?
15/5/2018
Manrai AK, Patel CJ, Ioannidis JA.
ver resumen
In this Viewpoint, John Ioannidis and colleagues discuss the challenges and potential benefits of defining what is “healthy” in an era of precision medicine, when defining normal will require that each person be assigned to an increasingly narrow and granular reference population.

2014 Guideline for Management of High Blood Pressure
5/2/2014
James PA, Oparil S, Carter BL, et al.
ver resumen
In the report from the panel members appointed to the Eighth Joint National Committee (JNC 8), the guideline authors provide evidence-based recommendations for the management of hypertension including specific goals by age, race, and comorbidities.

The Language of Power in Clinical Encounters
24/4/2018
Oldfield BJ.
ver resumen
This Arts and Medicine essay discusses the relevance of hip-hop musician Kendrick Lamar’s music and lyrics to the health challenges of urban youth and argues for physician literacy that incorporates the arts that are important to patients.

Effect of Increased Water Intake on Kidney Function Decline in Chronic Kidney Disease
8/5/2018
Clark WF, Sontrop JM, Huang S, et al.
ver resumen
This randomized clinical trial compares the effects of coaching patients with chronic kidney disease to increase vs maintain or reduce their free water intake on change in their estimated glomerular filitration rate at 12 months.

Anesthesiologist’s Meditations on Death and Life After a Patient’s Death During Surgery
8/5/2018
Shillcutt SK.
ver resumen
In this narrative medicine essay, an anesthesiologist shares her grief and takes stock of what she has and loves after the loss of a young patient in the operationg room.

Effect of Nitrofurantoin vs Fosfomycin on Uncomplicated Lower UTI in Women
1/5/2018
Huttner A, Kowalczyk A, Turjeman A, et al.
ver resumen
This randomized clinical trial compares the clinical and microbiologic efficacy of 5-day nitrofurantoin vs single-dose fosfomycin in women with uncomplicated urinary tract infection (UTI).

The Microbiome and Risk for Atherosclerosis
14/5/2018
Komaroff AL.
ver resumen
This Viewpoint discusses the role the human gut microbiome may play in the development and progression of atherosclerosis, both by influencing risk factors and by direct effects on the inflammation and vulnerability of endovascular plaques.

US Burden of Diseases, Injuries, and Disease Risk Factors, 1990-2016
10/4/2018
, Mokdad AH, Ballestros K, et al.
ver resumen
In this study, Global Burden of Disease investigators characterize trends in mortality, life expectancy, and prevalence associated with most common diseases and disease and mortality risk factors in the United States between 1990 and 2016.

Mortality Associated With Use of SGLT-2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors for Type 2 Diabetes
17/4/2018
Zheng SL, Roddick AJ, Aghar-Jaffar R, et al.
ver resumen
This network meta-analysis of randomized clinical trials that involved compares the effect of SGLT-2 inhibitors vs DPP-4 inhibitors vs GLP-1 agonists on mortality and cardiovascular events among patients with type 2 diabetes.

Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications in Gestational Diabetes
1/5/2018
Sénat M, Affres H, Letourneau A, et al.
ver resumen
This noninferiority randomized clinical trial compares the effects of glyburide vs subcutaneous insulin on macrosomia, neonatal hypoglycemia, and hyperbilirubinemia in infants born to women with gestational diabetes.

Will Nutritional Information Calories on Menus Lead to Healthier Choices?
15/5/2018
Rubin R.
ver resumen
This Medical News Story discusses the effectiveness of posting calories and other nutrition information on restaurant menus.

Feasibility of Airway Transplantation Using a Bioengineered Stented Aortic Allograft
20/5/2018
Martinod E, Chouahnia K, Radu DM, et al.
ver resumen
This case series describes 90-day mortality of patients who required tracheal, bronchial, or carinal reconstruction using stented aortic allografts supported by muscle flaps for treatment of inoperable airway disease including lung cancer, tracheal stenosis, or tracheomalacia.

Is Direct Primary Care a Game Changer?
22/5/2018
Rubin R.
ver resumen
This Medical News story discusses the pros and cons of direct primary care, whose practitioners don’t accept insurance and instead charge a membership fee to cover services.

How to Mentor Millennials
17/4/2018
Waljee JF, Chopra V, Saint S.
ver resumen
In this narrative medical essay, the authors present 3 scenarios exemplifying the collision between mentoring expectations among millennials and older generation faculty and proposes strategies to bridge generational divides and engage the next generation of physicians.

Prostate-Specific Antigen (PSA) Screening for Prostate Cancer
8/5/2018
Carter H.
ver resumen
Prostate-specific antigen (PSA)–based testing for detection of prostate cancer has remained controversial since its widespread adoption by clinicians in the United States in the late 1980s. Although measurement of PSA blood levels was approved in 1995 by the US Food and Drug Administration for early detection, PSA levels are not specific for prostate cancer or the more aggressive forms of the disease, which include approximately 1 in 3 newly diagnosed prostate cancers. In a randomized screening trial that included 162 388 patients, low specificity resulted in prostate biopsies in 20% of men screened, cancer was not detected in 3 of every 4 biopsies performed, and 70% of cancers detected in the screening group were found to be low grade (nonaggressive form). Prostate biopsies carry the risk of bleeding and infection requiring hospitalization in from 0.5% to 6.9% of men. However, these harms are less concerning than the rates of overdiagnosis (ie, detection of cancers that would not have been detected during life in the absence of screening), estimated to be from 23% to 42% in the US population and as high as 67% in a randomized screening trial conducted in Europe. If treated, these men risk a reduction in quality of life in urinary, sexual, and bowel domains without the benefit of extending life, because they would not have known about their cancer in the absence of screening.







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