JAMA más leídos

JAMA más leídos 2017-01-13T09:38:31+00:00

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JAMA - más leídos

Effect of Early Surgery vs Physical Therapy on Knee Function in Nonobstructive Meniscal Tears
2/10/2018
van de Graaf VA, Noorduyn JA, Willigenburg NW, et al.
ver resumen
This noninferiority trial compares the effects of arthroscopic partial meniscectomy vs physical therapy on patient-reported knee function in patients with meniscal tears.

Management of Chronic Wounds—2018
9/10/2018
Jones R, Foster DS, Longaker MT.
ver resumen
This Clinical Update summarizes options for chronic wound management in ambulatory settings, including use of standard gauze, negative-pressure wound therapy, advanced dressings (alginates, foams, hydrocolloids, and hydrogels), and adjuvant wound therapies.

Antibiotics for Sepsis
9/10/2018
Klompas M, Calandra T, Singer M.
ver resumen
This Viewpoint makes the case that the importance of early detection of sepsis and the need for rapid antibiotics in patients with definite infection and possible septic shock has likely led to overuse of antibiotics in patients who might not need them, and argues for testing to confirm infection in non-shock patients in place of rapid empirical antimicrobial treatment.

Consensus Definitions for Sepsis and Septic Shock
23/2/2016
Singer M, Deutschman CS, Seymour C, et al.
ver resumen
This article presents updated definitions of and clinical criteria for diagnosing sepsis and septic shock based on recommendations from an expert task force.

Effect of Piperacillin-Tazobactam vs Meropenem in Escherichia coli or Klebsiella pneumoniae Infection
11/9/2018
Harris PA, Tambyah PA, Lye DC, et al.
ver resumen
This noninferiority trial compares the effects of piperacillin-tazobactam vs meropenem on mortality in patients with bloodstream infection caused by ceftriaxone-nonsusceptible Escherichia coli or Klebsiella pneumoniae.

2014 Guideline for Management of High Blood Pressure
5/2/2014
James PA, Oparil S, Carter BL, et al.
ver resumen
In the report from the panel members appointed to the Eighth Joint National Committee (JNC 8), the guideline authors provide evidence-based recommendations for the management of hypertension including specific goals by age, race, and comorbidities.

Algorithm-Based Therapy vs Usual Care for Patients with Staphylococcal Bacteremia
25/9/2018
Holland TL, Raad I, Boucher HW, et al.
ver resumen
This noninferiority trial compares the effects on clinical success and adverse events of an algorithm that defines diagnostic evaluation, antibiotic selection, and duration of therapy for staphylococcal bacteremia vs standard clinical care.

Immune Checkpoint Inhibitor Toxicity
4/10/2018
Johnson DB, Chandra S, Sosman JA.
ver resumen
This JAMA Insights reviews the clinical presentation and management of the most common and severe immune checkpoint inhibitor toxicities.

Unproven but Profitable: The Boom in US Stem Cell Clinics
9/10/2018
Rubin R.
ver resumen
This Medical News & Perspectives article examines the proliferation of US clinics offering unproven stem cell therapies.

USPSTF Recommendation: Behavioral Interventions to Prevent Adult Obesity-Related Outcomes
18/9/2018
, Curry SJ, Krist AH, et al.
ver resumen
This 2018 Recommendation Statement from the US Preventive Services Task Force recommends that clinicians offer or refer adults with a body mass index of 30 or higher to intensive, multicomponent behavioral interventions (B recommendation).

From Lifespan to Healthspan
2/10/2018
Olshansky S.
ver resumen
This viewpoint discusses increased life expectancy and the initiatives to address the risks and unintended consequences of living longer.

Aging as a Biological Target for Prevention and Therapy
2/10/2018
Barzilai N, Cuervo A, Austad S.
ver resumen
This Viewpoint discusses targeting fundamental biological aging processes through nutritional, genetic, and pharmacologic interventions to delay or prevent the onset or progression of multiple chronic diseases and debilities typically observed in older humans to enhance and extend both health and longevity.

Vulnerability to Pandemic Flu Could Be Greater Today Than a Century Ago
16/10/2018
Voelker R.
ver resumen
Infectious disease threats expert Michael Osterholm, PhD, MPH, discusses how the United States and the rest of the world may fare if another 1918-like influenza epidemic strikes.

Rare Infection Linked With SGLT-2 Inhibitor Use
2/10/2018
Voelker R.
ver resumen
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors used to treat adults with type 2 diabetes have been linked with necrotizing fasciitis of the perineum, a serious rare infection also known as Fournier gangrene, the FDA has warned.

Notice of Retraction: Wansink et al
19/9/2018
Bauchner H.
ver resumen
This notice is to alert readers to the retraction of articles written by Brian Wansink and published in JAMA and the JAMA Network journals.

Association of Clinical Specialty With Symptoms of Burnout and Regret Among US Resident Physicians
18/9/2018
Dyrbye LN, Burke SE, Hardeman RR, et al.
ver resumen
This survey study investigates risk factors for symptoms of burnout and career choice regret among US physicians during their second year of residency.

Coagulation Test in Oral Anticoagulant Therapy
9/10/2018
Sholzberg M, Xu Y.
ver resumen
A 74-year-old man taking rivaroxaban for atrial fibrillation developed a subdural hematoma and had an elevated prothrombin time (PT) with normal activated partial thromboplastin time (aPTT) and platelets prior to planned surgical evacuation. How do you interpret the results?

Treatment Algorithms for Staphylococcal Bacteremia
25/9/2018
Perencevich EN, Malani PN.
ver resumen
Antimicrobial resistance is among the most important threats to human health. Lost in the episodic outbreaks of emerging pathogens such as 2009 H1N1 influenza, Ebola, and Zika virus has been the steady increase in resistance to commonly used antibiotics in frequently seen bacterial infections. Confronting antimicrobial resistance requires investment in 3 critical areas including (1) antimicrobial discovery, (2) rapid diagnostics, and (3) infection prevention and antimicrobial stewardship. In particular, algorithms based on clinical practice guidelines, that promote appropriate antibiotics and durations of therapy and limit unnecessary treatment, have the potential to enhance care for individual patients and improve public health more broadly.

Low-Fat vs Low-Carbohydrate Diet on Weight Loss in Overweight Adults
20/2/2018
Gardner CD, Trepanowski JF, Del Gobbo LC, et al.
ver resumen
This randomized clinical trial compares the effects of a healthy low-fat vs a healthy low-carbohydrate diet on 12-month weight change among adults aged 18 to 50 years with a body mass index of 28 to 40 without diabetes, and investigates modification of the diet effect by genotype pattern or insulin secretion.

Association Between the Experimental Kickoff Rule and Concussion Rates in Ivy League Football
1/10/2018
Wiebe DJ, D’Alonzo BA, Harris R, et al.
ver resumen
This before-after study investigates changes in concussion among Ivy League football players after implementation of a 2016 rule change intended to land more kickoffs in the end zone and reduce player injury.







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